Detection of C-type natriuretic peptide compared with brain and atrial natriuretic peptide transcripts in human heart by the polymerase chain reaction
نویسنده
چکیده
C-type natriuretic peptide (CNP), initially isolated from porcine brain [3], is the most recently characterized member of the natriuretic peptide family. The human CNP gene consists of at least two exons and an intron [4]. Whereas synthesis of atrial and brain natriuretic peptides (ANP and BNP) has been demonstrated mainly in the heart, but also in various other organs [2, 5], CNP m R N A in man has so far been found only in the central nervous system. We have investigated human cardiac tissues for CNP expression and compared the abundance of CNP transcripts with that of ANP and BNP.
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تاریخ انتشار 2004